Endocrine Abstracts

Abstract: Glomerular hyperfiltration has been suggested as a possible mechanism linking obesity and chronic kidney disease, independently of classical risk factors such as diabetes. In terms of determining the creatinine clearance has numerous drawbacks, in clinical use are predictors of glomerular filtration rate (GFR) which show varying degrees of accuracy in obese patients. The aim of our study was to determine whether it is in our group of obese patients without type 2 dia...

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN1) associated thymic carcinoids (Th-NETs) are rare and have poor prognosis. Cushing syndrome (CS) caused by Th-NET in MEN1 syndrome is extremely rare.Case report: We report a case of a 55-year-old man with CS at presentation due to ectopic ACTH production in MEN1 syndrome. Thirty years ago, this patient had total gastric resection due to Zollinger-Ellison’s syndrome and extirpation of tw...

Balance between pro- and anti- inflammatory cytokines is necessary for the physiological functioning of the immune system. A chronic systemic inflammation is one of the causes of insulin resistance in obesity.The aim of this study was to investigate the pro-inflammatory cytokines and visfatin response to an single bout acute exercise in athletes and non-athletes, as well as the possible relationship pro-inflammatory cytokines with body composition and in...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...

The aim of this study was to investigate adipocytokine responses to an single bout acute exercise in elite athletes with a low percentage of body fat, elite athletes with a high percentage of body fat and sedentary controls. Sixteen athletes with low percentage of body fat (volleyball players, low fat athletes group, LFAG), 15 athletes with high percentage of body fat (the elite water polo players, high fat athletes group, HFAG) and 15 sedentary subjects participated in this s...

Adrenal hemangioma is a rare adrenal tumour usually presented as incidental finding in asymptomatic patients. Due to its radiographic features sometimes it’s difficult to differentiate them from other malignant lesions. We present a 55-years-old men admitted to our department with adrenal incidentaloma size 5×4 cm confirmed by MSCT scan. Active phaeochromocythoma was excluded by normal urinary catecholamines. Endocrine evaluations revealed normal midnight cortisol, w...

Introduction: Turner’s syndrome (TS) or Ullrich-Turner’s syndrome is genetic condition that affects only females. It is characterized by typical physical features and complete or part absence of one of the X chromosomes. Women with TS have been reported to be at increased risk of autoimmune diseases as compared with other women. Idiopathic thrombocytopenic purpura (ITP), isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other c...

Introduction: After gastric bypass, gastric secretion decreased and resorption of minerals and vitamins may be compromised. Lower resorpion of serum calcium and vitamin D could stimulate PTH secretion after restictive and malabsorptive bariatric procedures.Methods: We have measured serum calcium, D vitamin and PTH in patients (n=50, 17 males and 33 females) 6 and 12 months after R en Y gastric bypass, 38.6±12.6 years of age, with BMI 43&#17...

Ganglioneuromas are benign sympathetic tissue tumors originating from neural crest cells. A 40-year-old female patient, was admitted to our department for endocrinological evaluation of incidentally discovered tumor of right adrenal gland. For about a year before admission she had a pain under the right costal arch. An ultrasound and computed tomography (CT) showed 2 ovoid cystical tumors of right adrenal (34 and 32 mm, respectively). Three months prior admission she had sever...

In most obese patients, obesity is associated with a low-grade inflammation of white adipose tissue resulting from chronic activation of the innate immune system and which can subsequently lead to insulin resistance, impaired glucose tolerance and even diabetes. It is still not clear role of acquired immune response in obesity and related comorbidites such as asthma, cancer or autoimmune diseases. The aim of our study was to compare level s of IL-17 and IL23 in sever obese wom...